Mercedes-Benz CLS450 Fuel Economy History

MPG by year — EPA official data.

Best MPG Year

2021

26 MPG combined

Latest Model

2021

26 MPG combined

Year	Engine	City	Hwy	Combined	Fuel Cost/yr
2021	Premium Hybrid	23	30	26	$3,150	Details →
2020	Premium Hybrid	24	31	26	$3,150	Details →
2019	Premium Hybrid	24	31	26	$3,150	Details →