Mercedes-Benz E350 4matic Fuel Economy History
MPG by year — EPA official data.
Best MPG Year
2026
27 MPG combined
Latest Model
2026
27 MPG combined
| Year | Engine | City | Hwy | Combined | Fuel Cost/yr | |
|---|---|---|---|---|---|---|
| 2026 | Premium Hybrid | 24 | 33 | 27 | $3,050 | Details → |
| 2025 | Premium Hybrid | 24 | 33 | 27 | $3,050 | Details → |
| 2024 | Premium Hybrid | 24 | 33 | 27 | $3,050 | Details → |
| 2023 | Premium | 21 | 30 | 24 | $3,400 | Details → |
| 2022 | Premium | 21 | 29 | 24 | $3,400 | Details → |
| 2021 | Premium | 22 | 30 | 25 | $3,250 | Details → |
| 2020 | Premium | 22 | 30 | 25 | $3,250 | Details → |
| 2016 | Premium | 20 | 27 | 23 | $3,550 | Details → |
| 2015 | Premium | 20 | 27 | 23 | $3,550 | Details → |
| 2014 | Premium | 20 | 27 | 23 | $3,550 | Details → |
| 2013 | Premium or E85 FFV | 19 | 28 | 22 | $3,700 | Details → |
| 2012 | Premium | 19 | 28 | 22 | $3,700 | Details → |
| 2011 | Premium | 17 | 24 | 19 | $4,300 | Details → |
| 2010 | Premium | 17 | 24 | 19 | $4,300 | Details → |
| 2009 | Premium | 16 | 22 | 18 | $4,550 | Details → |
| 2008 | Premium | 16 | 22 | 18 | $4,550 | Details → |
| 2007 | Premium | 16 | 23 | 19 | $4,300 | Details → |
| 2006 | Premium | 16 | 23 | 19 | $4,300 | Details → |