Mercedes-Benz E450 4matic Fuel Economy History
MPG by year — EPA official data.
Best MPG Year
2023
26 MPG combined
Latest Model
2026
25 MPG combined
| Year | Engine | City | Hwy | Combined | Fuel Cost/yr | |
|---|---|---|---|---|---|---|
| 2026 | Premium Hybrid | 22 | 31 | 25 | $3,250 | Details → |
| 2025 | Premium Hybrid | 22 | 31 | 25 | $3,250 | Details → |
| 2024 | Premium Hybrid | 22 | 31 | 25 | $3,250 | Details → |
| 2023 | Premium Hybrid | 23 | 31 | 26 | $3,150 | Details → |
| 2022 | Premium Hybrid | 23 | 30 | 25 | $3,250 | Details → |
| 2021 | Premium Hybrid | 23 | 30 | 26 | $3,150 | Details → |
| 2020 | Premium | 20 | 28 | 23 | $3,550 | Details → |
| 2019 | Premium | 20 | 28 | 23 | $3,550 | Details → |