Mercedes-Benz E450 4matic All-Terrain (wagon) Fuel Economy History

MPG by year — EPA official data.

Best MPG Year

2026

25 MPG combined

Latest Model

2026

25 MPG combined

Year	Engine	City	Hwy	Combined	Fuel Cost/yr
2026	Premium Hybrid	22	31	25	$3,250	Details →
2025	Premium Hybrid	22	31	25	$3,250	Details →
2024	Premium Hybrid	22	31	25	$3,250	Details →
2023	Premium Hybrid	21	28	24	$3,400	Details →
2022	Premium Hybrid	21	28	24	$3,400	Details →
2021	Premium Hybrid	22	28	24	$3,400	Details →